To die or not to die:Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
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- Autor/in:
- Erscheinungsjahr:
- 2018
- Medientyp:
- Text
- Beschreibung:
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Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1-mediated apoptosis and necroptosis in response to diverse stimuli relevant to inflammation, infection, genotoxic stress and chemotherapy.
- Lizenz:
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- info:eu-repo/semantics/restrictedAccess
- Quellsystem:
- Forschungsinformationssystem des UKE
Interne Metadaten
- Quelldatensatz
- oai:pure.atira.dk:publications/0c4d9687-50a1-420b-b8a7-b1695fc6e60f