Retrospective analysis of three induction chemotherapy regimens in acute myeloid leukemia including CPX-351, cytarabine/daunorubicin with and without the addition of cladribine

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Erscheinungsjahr:
2022
Medientyp:
Text
Beschreibung:
  • Recently new treatments for acute myeloid leukemia (AML) emerged, including regimens like
    CPX-351 and cladribine with cytarabine and daunorubicin (DA þ C), demonstrating improved
    survival in patient subsets. This retrospective analysis is comparing the outcome of 124 patients
    treated with cytarabine and daunorubicin (DA; n ¼ 54), CPX-351 (n ¼ 26) and DA þ C (n ¼ 44).
    Complete response rate following one cycle of therapy was increased in DA þ C (62%) compared
    to CPX-351 (42%) and DA (50%). CPX-351 demonstrated a significant increased survival post
    allogenic stem cell transplantation against DA (hazard ratio (HR): 4.9; 95% confidence interval
    (95%CI): 1.1–21, p ¼ 0.03). Median survival was reached for DA (5.6 years) but not for DA þ C or
    CPX-351. Subgroup analysis showed that AML with myelodysplasia-related changes and therapy-
    related AML treated with CPX-351 had increased survival compared to DA (HR: 5.2; 95%CI:
    1.2–22; p ¼ 0.03). Our findings point twoards a CPX-351 superiority. However, the use of DA þ C
    should be further evaluated in comparative studie.
  • Recently new treatments for acute myeloid leukemia (AML) emerged, including regimens like CPX-351 and cladribine with cytarabine and daunorubicin (DA + C), demonstrating improved survival in patient subsets. This retrospective analysis is comparing the outcome of 124 patients treated with cytarabine and daunorubicin (DA; n = 54), CPX-351 (n = 26) and DA + C (n = 44). Complete response rate following one cycle of therapy was increased in DA + C (62%) compared to CPX-351 (42%) and DA (50%). CPX-351 demonstrated a significant increased survival post allogenic stem cell transplantation against DA (hazard ratio (HR): 4.9; 95% confidence interval (95%CI): 1.1-21, p = 0.03). Median survival was reached for DA (5.6 years) but not for DA + C or CPX-351. Subgroup analysis showed that AML with myelodysplasia-related changes and therapy-related AML treated with CPX-351 had increased survival compared to DA (HR: 5.2; 95%CI: 1.2-22; p = 0.03). Our findings point twoards a CPX-351 superiority. However, the use of DA + C should be further evaluated in comparative studies.

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  • info:eu-repo/semantics/closedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/e12df720-c248-4c84-a8ad-3369516aa4f5