Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.

Link:
Autor/in:
Erscheinungsjahr:
2011
Medientyp:
Text
Schlagworte:
  • Animals
  • Humans
  • Immunohistochemistry
  • Time Factors
  • Disease Models, Animal
  • Mice
  • Reverse Transcriptase Polymerase Chain Reaction
  • Promoter Regions, Genetic
  • Mice, Transgenic
  • Gene Expression Regulation/drug effects
  • Mice, SCID
  • DNA, Viral/metabolism
  • Active Transport, Cell Nucleus
  • Albumins/genetics
  • Antiviral Agents/*administration & dosage
  • Guanine/administration & dosage/analogs & derivatives
  • Hepatitis B/diagnosis/*drug therapy/genetics
  • Hepatitis B virus/*drug effects/genetics/growth & development
  • Hepatocytes/*drug effects/metabolism/*transplantation
  • Interferon-alpha/*administration & dosage
  • Liver/*drug effects/metabolism/virology
  • RNA, Viral/metabolism
  • STAT1 Transcription Factor/genetics/metabolism
  • *Transplantation Chimera
  • Urokinase-Type Plasminogen Activator/genetics
  • Animals
  • Humans
  • Immunohistochemistry
  • Time Factors
  • Disease Models, Animal
  • Mice
  • Reverse Transcriptase Polymerase Chain Reaction
  • Promoter Regions, Genetic
  • Mice, Transgenic
  • Gene Expression Regulation/drug effects
  • Mice, SCID
  • DNA, Viral/metabolism
  • Active Transport, Cell Nucleus
  • Albumins/genetics
  • Antiviral Agents/*administration & dosage
  • Guanine/administration & dosage/analogs & derivatives
  • Hepatitis B/diagnosis/*drug therapy/genetics
  • Hepatitis B virus/*drug effects/genetics/growth & development
  • Hepatocytes/*drug effects/metabolism/*transplantation
  • Interferon-alpha/*administration & dosage
  • Liver/*drug effects/metabolism/virology
  • RNA, Viral/metabolism
  • STAT1 Transcription Factor/genetics/metabolism
  • *Transplantation Chimera
  • Urokinase-Type Plasminogen Activator/genetics
Beschreibung:
  • Interferon (IFN)-? therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-?-mediated induction of antiviral defense mechanisms in human hepatocytes.
  • Interferon (IFN)-? therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-?-mediated induction of antiviral defense mechanisms in human hepatocytes.
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE
Interne Metadaten
Quelldatensatz
oai:pure.atira.dk:publications/e0dfc1ad-1965-4c9d-b52d-25e3854d0ace