Angiogenesis index CD105 (endoglin)/CD31 (PECAM-1) as a predictive factor for invasion and proliferation in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
Neoplasms, Cystic, Mucinous, and Serous blood supply
Neovascularization, Pathologic metabolism
Pancreatic Neoplasms blood supply
Receptors, Cell Surface analysis
Adult
Germany
Humans
Male
Aged
Female
Middle Aged
Aged, 80 and over
Immunohistochemistry
Prognosis
Time Factors
Retrospective Studies
Neoplasm Staging
Cell Proliferation
Kaplan-Meier Estimate
Tumor Markers, Biological analysis
Antigens, CD analysis
Antigens, CD31 analysis
Carcinoma, Pancreatic Ductal blood supply
Carcinoma, Papillary blood supply
Ki-67 Antigen analysis
Neoplasm Invasiveness
Neoplasms, Cystic, Mucinous, and Serous blood supply
Neovascularization, Pathologic metabolism
Pancreatic Neoplasms blood supply
Receptors, Cell Surface analysis
Beschreibung:
Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is an increasingly diagnosed entity since its definition by the World Health Organization in 1996. It has a broad clinical spectrum ranging from benign to malignant tumors. Optimum treatment is controversial and a better understanding of the development of IPMN of the pancreas and identification of potential prognostic factors will help to address this. Angiogenesis plays an elementary role in the development of malignant tumors and may well also be important in the development of IPMN of the pancreas. Therefore we investigated endothelial cell marker CD31 (PECAM-1) and angiogenesis associated marker CD105 (endoglin) by immunohistochemistry.
Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is an increasingly diagnosed entity since its definition by the World Health Organization in 1996. It has a broad clinical spectrum ranging from benign to malignant tumors. Optimum treatment is controversial and a better understanding of the development of IPMN of the pancreas and identification of potential prognostic factors will help to address this. Angiogenesis plays an elementary role in the development of malignant tumors and may well also be important in the development of IPMN of the pancreas. Therefore we investigated endothelial cell marker CD31 (PECAM-1) and angiogenesis associated marker CD105 (endoglin) by immunohistochemistry.