Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression

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Erscheinungsjahr:
2017
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Text
Beschreibung:
  • The expression pattern of the ectonucleotidases CD39 and CD73 on NK cells was examined in PBMC of 61 HIV-1 infected patients. Increased frequencies of CD39CD56 NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4+ T cell count and CD8+ T cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with Aryl hydrocarbon receptor (AHR) and IL-10 expression. Here, we provide first evidence of increased CD39CD56 NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis.

Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/9d67816f-661d-4cc9-a62a-b199d97c80e6