Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis
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- Erscheinungsjahr:
- 2014
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Hyperferritinemia is a hallmark of hemophagocytic lymphohistiocytosis (HLH). In the HLH-2004 criteria, a ferritin value >500 µg/L is considered positive. However, this level was not determined based on evidence. We compared 123 patients with HLH and 320 patients with other hyperferritinemic conditions, calculated a receiver-operating characteristic, and determined sensitivity and specificity for different values. At 2,000 µg/L a trade-off is reached with sensitivity at 70% and specificity at 68%. If familial HLH and virus-associated acquired HLH are analyzed separately, sensitivity and specificity are similar for this level. The results may guide a potential modification of the current HLH criteria. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
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- info:eu-repo/semantics/restrictedAccess
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- Forschungsinformationssystem des UKE
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- oai:pure.atira.dk:publications/45f32821-88b3-4b87-a051-02a9c9703c2e