Molecular targeting in combination with platinum-based chemoradiation in head and neck cancer treatment

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Autor/in:
Erscheinungsjahr:
2016
Medientyp:
Text
Schlagworte:
  • dk/atira/pure/publikationen_lom_relevant/cancer
  • Cancer Medicine – University Cancer Center Hamburg (UCCH)
Beschreibung:
  • BACKGROUND: Significant evidence exists supporting the use of platinum-based chemoradiation (CRT) as a primary curative approach in locoregionally advanced head and neck cancer (LA-HNSCC). Despite these aggressive protocols, 70% of patients die within five years due to locoregional recurrence or distant metastasis. To increase the response and survival of HNSCC patients, CRT has been combined with molecular agents targeting distinct kinases.

    METHODS: This study was performed using a systematic literature review.

    RESULTS: The effect of targeted therapy on patient survival in the context of CRT remains controversial, with toxicities tending to be more severe but still acceptable.

    CONCLUSIONS: Supplementing CRT with target therapeutics might only improve survival in some LA-HNSCC patients. Therefore, future studies must address the underlying biological mechanisms which can have an impact on treatment response. Such knowledge is essential in order to facilitate the effective and personalized treatment of LA-HNSCC patients by combining CRT and targeted therapy. This article is protected by copyright. All rights reserved.

Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/c30b66b4-7c9c-4c0b-83e9-3ab068fc6463