Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica Serovar Hadar resistant to Tigecycline.

Link:
Autor/in:
Erscheinungsjahr:
2009
Medientyp:
Text
Beschreibung:
  • A Salmonella enterica Serovar Hadar strain resistant to tigecycline (MIC 16 mug/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wildtype ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate thus implicates ramR in resistance to tigecycline.
  • A Salmonella enterica Serovar Hadar strain resistant to tigecycline (MIC 16 mug/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wildtype ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate thus implicates ramR in resistance to tigecycline.
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

Interne Metadaten
Quelldatensatz
oai:pure.atira.dk:publications/db40c26e-0f9b-459e-b41c-356a3ee6ffcb