49 Einträge gefunden

1. The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

   1. Tian, Ling-Yu
   2. Smit, Daniel J.
   3. Jücker, Manfred

   2023 - Forschungsinformationssystem des UKE - frei zugänglich
2. SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model

   1. Ehm, Patrick
   2. Rietow, Ruth
   3. Wegner, Wiebke
   4. Bußmann, Lara
   5. Kriegs, Malte
   6. Dierck, Kevin
   7. Horn, Stefan

   2023 - Forschungsinformationssystem des UKE - frei zugänglich
3. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases

   1. Ehm, Patrick A H
   2. Linnebacher, Michael
   3. Block, Andreas
   4. Rehbach, Christoph
   5. Jücker, Manfred

   2023 - Forschungsinformationssystem des UKE
4. Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants

   1. Ehm, Patrick
   2. Nelson, Nina
   3. Giehler, Susanne
   4. Schaks, Matthias
   5. Bettin, Bettina
   6. Kirchmair, Johannes
   7. Jücker, Manfred

   2023 - Forschungsinformationssystem des UKE
5. Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021

   1. Ehm, Patrick
   2. Bettin, Bettina
   3. Jücker, Manfred

   2023 - Forschungsinformationssystem des UKE
6. JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative Neoplasm (MPN)

   1. Glück, Madeleine
   2. Dally, Lina
   3. Jücker, Manfred
   4. Ehm, Patrick

   2022 - Forschungsinformationssystem des UKE
7. AKT Isoforms as a Target in Cancer and Immunotherapy

   1. Smit, Daniel J.
   2. Jücker, Manfred

   2022 - Forschungsinformationssystem des UKE
8. The Functional Role of Extracellular Matrix Proteins in Cancer

   1. Popova, Nadezhda V
   2. Jücker, Manfred

   2022 - Forschungsinformationssystem des UKE - frei zugänglich
9. Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

   1. Elakad, Omar
   2. Häupl, Björn
   3. Labitzky, Vera
   4. Yao, Sha
   5. Küffer, Stefan
   6. von Hammerstein-Equord, Alexander
   7. Danner, Bernhard C

   2022 - Forschungsinformationssystem des UKE - frei zugänglich
10. Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL)

    1. Ehm, Patrick
    2. Grottke, Astrid
    3. Bettin, Bettina
    4. Jücker, Manfred

    2022 - Forschungsinformationssystem des UKE
11. Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis

    1. Hinz, Nico
    2. Baranowsky, Anke
    3. Horn, Michael
    4. Kriegs, Malte
    5. Sibbertsen, Freya
    6. Smit, Daniel J
    7. Clezardin, Philippe

    2021 - Forschungsinformationssystem des UKE - frei zugänglich
12. Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy

    1. Smit, Daniel J
    2. Pantel, Klaus
    3. Jücker, Manfred

    2021 - Forschungsinformationssystem des UKE
13. AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2

    1. Nelson, Nina
    2. Razeto, Adelia
    3. Gilardi, Alessia
    4. Grättinger, Mira
    5. Kirchmair, Johannes
    6. Jücker, Manfred

    2021 - Forschungsinformationssystem des UKE
14. AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review

    1. Hinz, Nico
    2. Jücker, Manfred

    2021 - Forschungsinformationssystem des UKE - frei zugänglich
15. Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer

    1. Hofmann, Bianca T
    2. Picksak, Aeint-Steffen
    3. Kwiatkowski, Marcel
    4. Grupp, Katharina
    5. Jücker, Manfred
    6. Bachmann, Kai
    7. Mercanoglu, Baris

    2021 - Forschungsinformationssystem des UKE - frei zugänglich
16. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

    1. Ecker, Veronika
    2. Stumpf, Martina
    3. Brandmeier, Lisa
    4. Neumayer, Tanja
    5. Pfeuffer, Lisa
    6. Engleitner, Thomas
    7. Ringshausen, Ingo

    2021 - Forschungsinformationssystem des UKE - frei zugänglich
17. The Role of mTOR Signaling as a Therapeutic Target in Cancer

    1. Popova, Nadezhda V
    2. Jücker, Manfred

    2021 - Forschungsinformationssystem des UKE - frei zugänglich
18. Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo

    1. Schulte, Alexander
    2. Ewald, Florian
    3. Spyra, Melanie
    4. Smit, Daniel J
    5. Jiang, Wei
    6. Salamon, Johannes
    7. Jücker, Manfred

    2020 - Forschungsinformationssystem des UKE
19. Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer

    1. Schaks, Matthias
    2. Allgoewer, Kristina
    3. Nelson, Nina
    4. Ehm, Patrick
    5. Heumann, Asmus
    6. Ewald, Florian
    7. Schumacher, Udo

    2020 - Forschungsinformationssystem des UKE
20. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

    1. Nelson, Nina
    2. Wundenberg, Torsten
    3. Lin, Hongying
    4. Rehbach, Christoph
    5. Horn, Stefan
    6. Windhorst, Sabine
    7. Jücker, Manfred

    2020 - Forschungsinformationssystem des UKE